In meta-analysis, it is common to talk about random- and fixed-effect models. This can get pretty confusing, because fixed- and random-effects models exist outside meta-analysis as well. As a result, there is a short and a long answer to this…

In meta-analysis, it is common to talk about random- and fixed-effect models. This can get pretty confusing, because fixed- and random-effects models exist outside meta-analysis as well. As a result, there is a short and a long answer to this…

Meta-analysis is the statistical aggregation of data from a number of studies in order to answer a question. As an example, when considering the efficacy of a treatment, one may pool the results of multiple trials comparing the treatment to…

Meta-analysis is the statistical aggregation and analysis of data from multiple studies. When the studies included are properly selected and the data are aggregated appropriately, it uses more of the available information than a single study and so should be…

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## Why are drugs so disappointing?

No, this isn’t an extended post about reefer madness. It’s about that horrible gap between the excitement of a new therapy for an illness, and the results that eventually come out years later. One of my main interests is in…